Comparison of Lunesta vs Ambien

Many things can make you difficult in fall asleep or stay asleep. This kind of problem is medically termed as insomnia, and if you are suffering from this disease for more than one month, then you should see your doctor. They may prescribe changes to your lifestyle or sleeping habits. Suppose, those things do not treat your sleeping disorder, there are drugs that can help.

Lunesta and Ambien are belonged to prescription-only medication and these two pills are medically used for the treatment of insomnia. The FDA endorsed the utilization of Lunesta and Ambien in six trials in that one can get treated for insomnia.

Both of these two medicines have the generic variant. Eszopiclone is the generic name for brand Lunesta. Zolpidem is the generic name for brand Ambien. Both of these medicines belong to the narcotic hypnotic’s medication class. These pills are mostly recommended for individuals aged 18 years and older who experience annoyance sleeping.

Taking one of them might be exactly what you have to get a pleasant night’s sleep. Here we have compared mechanism of action, dosage, side effects, and interactions of drugs, and side effects of both medications.

Lunesta vs Ambien – Working function

These two medications reduce the brain activity and produce a calming effect. This made the peoples with insomnia to fall asleep or stay asleep. Both the medicines are engaged for short-term utilization. Yet they varied in their dosage strength and how long the effectiveness stays in your body.

For instance, Ambien is accessible in immediate release tablets of 5mg and 10mg. It’s also accessible in extended-release tablets of 6.25mg and 12.5mg, which is called Ambien CR.

Further, Lunesta is accessible in immediate release oral tablets of 1mg, 2mg, and 3mg. It isn’t accessible in a controlled release form. Yet Lunesta is considered to be longer acting substance. It might be more effective in helping you stay unconscious than the Ambien IR pill. Based on above things Ambien ER tablet may enable you to fall asleep longer.


The Lunesta 1mg dosage per day is usually recommended for both women and men. If the dosage does not work, your doctor will increase the strength of the dosage gradually. Usually, 5mg of Ambien IR per day is prescribed for women and 5mg to 10mg once in a day for men. The Ambien IR normal dosage strength is 6.25mg that is recommended for the women and 6.5mg to 12.5mg for men.

Lunesta and Ambien adverse effects

Here we listed some of the most common and exceptional adverse effects of both drugs.

  • Lightheadedness
  • Dizziness
  • Loss of memory
  • Confusion
  • Depression
  • Suicidal ideations
  • Hallucinations
  • Behavior changes

When you drink alcohol or utilize any other CNS sedative drugs while taking either of these medications, you have to face serious adverse effects. You ought not to be mix sleeping pills and alcohol.

Medication Interactions

Some of the following medications ought to be taken with Ambien or Lunesta sleep pills.

  • Muscle relaxants
  • Allergy pills
  • Anti-anxiety drugs
  • Narcotic pain relief medications
  • Sodium oxybate
  • Cold and cough medicines that may determinant drowsiness

Tell your physicians and pharmacist about all the drugs that you are currently taking, including OTC(Over The Counter) pills, herbal products or supplements.